- 期刊
Poor Healing Capacity of Chronic Torn Supraspinatus Tendon
破裂的脊上肌腱癒合能力貧乏
摘要
Background. Tear of rotator cuff typically begins in the supraspinatus tendon, however healing capacity of torn supraspinatus tendon is unclear. The aims of this study were to measure the content of α1 type-I and α1 type-III procollagen mRNA from the torn edge of supraspinatus tendon and to estimate its healing capacity. Methods. Twenty torn supraspinatus tendon specimens were obtained from 20 completethickness tear patients. The control group consisted of six normal supraspinatus tendons obtained from other shoulder operation patients. The content of α1 type-l and Type-lll procollagen mRNA was measured semiquantitatively by RT-PCR. Results. mRNA levels of collagen I and III were lower in the torn supraspinatus group than in the normal group (p ＜ 0.001). There were no statistically significant differences between size of tear and duration of pain in mRNA levels of collagen I and III. Conclusions. This study revealed lower amounts of α1 type-l and type-Ill procollagen mRNA in torn rotator cuff which suggests that chronic torn supraspinatus tendons have a poor healing capacity. (Mid Taiwan J Med 2002;7:1-6)
並列摘要
Background. Tear of rotator cuff typically begins in the supraspinatus tendon, however healing capacity of torn supraspinatus tendon is unclear. The aims of this study were to measure the content of α1 type-I and α1 type-III procollagen mRNA from the torn edge of supraspinatus tendon and to estimate its healing capacity. Methods. Twenty torn supraspinatus tendon specimens were obtained from 20 completethickness tear patients. The control group consisted of six normal supraspinatus tendons obtained from other shoulder operation patients. The content of α1 type-l and Type-lll procollagen mRNA was measured semiquantitatively by RT-PCR. Results. mRNA levels of collagen I and III were lower in the torn supraspinatus group than in the normal group (p ＜ 0.001). There were no statistically significant differences between size of tear and duration of pain in mRNA levels of collagen I and III. Conclusions. This study revealed lower amounts of α1 type-l and type-Ill procollagen mRNA in torn rotator cuff which suggests that chronic torn supraspinatus tendons have a poor healing capacity. (Mid Taiwan J Med 2002;7:1-6)