- 期刊
99mTc-ECD Brain SPECT in Patients with Persistent Post-Concussion Syndrome after Mild Head Injury and Normal Computed Tomography
鎝-99m-ECD腦部單光子射出斷層掃描在評估輕微頭部外傷後有持續性腦震盪後症候群且其腦部電腦斷層為正常的病人
摘要
背景 腦震盪後症候群(post-concussion syndrome ， PCS)被定義為在輕微腦部外傷後,有三個或以上的臨床症狀(如頭痛、記憶衰退、失眠、焦慮、或暈眩)持續長達三個月以上。本研究之目的在於評估鎝-99m-ECD腦部單光子射出斷層掃描對於腦部輕微外 傷後的腦震盪後症候群持續三個月以上且在電腦斷層掃描檢查中沒有形態學上異常的病 人的可用性。 方法 本研究共包括了48個病人(20位男性及28位女性,年齡範圍從21歲至75歲)在 頭部外傷後苦於持續性的不適長達三個月以上。最常見的不過是頭痛、記憶衰退、失 眠、焦慮及暈眩。然而所有病人的腦部電腦斷層掃描卻沒有發現任何異常。所有的病人都接受鎝-99m-ECD腦部單光子射出斷層掃描。這些病人先前都沒有頭部創傷、中風、 情緒障礙或藥物及酒精濫用的病史。 結果 16位病人的檢查結果為正常而其他32位病人的鎝-99m-ECD 腦部單光子射出斷層掃描有不正常腦部血流改變的情形。 結論 和腦部電腦斷層掃描相比，鎝-99m-ECD腦部單光子射出斷層掃描在評估輕微腦部外傷後有持續性腦震盪後症候群且其腦部的形態學方面完整的病人的腦部血流改變的 情形是很有用的工具。(中台灣醫誌2002;7 :14-20 )
並列摘要
Background. Post-concussion syndrome (PCS) has been defined as a clinical state where 3 or more symptoms (such as headache, poor memory, insomnia, anxiety or dizziness, etc.) persist for more than 3 months after mild closed head trauma. The purpose of this study was to evaluate the potential usefulness of 99mTc-ECD brain single photon emission computed tomography (SPECT) scan in patients with PCS for more than 3 months and absence of morphological abnormalities on computed tomography (CT) scan after mild closed head injury. Methods. Our study included 48 patients (20 men and 28 women ranging in age from 21 to 75years) who suffered from persistent clinical complaints for more than 3 months after mild closed head trauma. The most common complaints were headache, poor memory, insomnia, anxiety and dizziness. However, brain CT scan was normal in all patients. All patients received 99mTc-ECD brain SPECT imaging. None of these patients had previous traumatic brain injury, CVA, psychiatric disorders or history of drug or alcohol abuse. Results. Sixteen patients had normal and 32 patients had abnormal 99mTc-ECD brain SPECT scans. Conclusions99m. Tc-ECD brain SPECT scanning is a useful imaging modality, as a complement to CT, for evaluating cerebral perfusion changes in morphologically intact brain regions in patients with persistent PCS following mild traumatic brain injury. (Mid Taiwan J Med 2002;7:14-20)