This research discusses the prospects of implementing comprehensive sexuality education in Taiwan. The sexuality education content of curriculum guidelines and textbooks was analyzed in conjunction with teacher interview data to examine possibilities and challenges related to implementing comprehensive sexuality education in secondary schools. On the basis of this analysis, the researchers identified problems that must be overcome if comprehensive sexuality education is to be successfully implemented locally and developed relevant suggestions. Curriculum guidelines and textbooks should be modified to enhance their comprehensiveness, and teachers' on-the-job training in sexuality education should be more interdisciplinary and integrated.