共軛亞麻油酸對人體身體組成之影響

The Effects of Conjugated Linoleic Acid on Body Composition in Humans

江筱慧(Hsiao-Hui Chiang) ； 王嬿婷(Yen-Ting Wang) ； 許美智(Mei-Chich Hsu)

《大專體育》 120期 (2012/06) Pp. 56-63

https://doi.org/10.6162/SRR.2012.120.09

摘要

共軛亞麻油酸為不易形成體脂肪的健康食品，此成分常見於減肥產品中。不同異構物之共軛亞麻油酸補充劑量、服用時間及運動計畫介入與否皆會影響體脂肪及瘦體組織的表現；由於異構物相互作用的特性，多數研究採用等比混合型式之補充劑，以增加改變身體組成及血脂質等效益；此外也發現每天補充3.4g共軛亞麻油酸為一安全劑量。但共軛亞麻油酸對於降低體脂肪的影響並無劑量反應的依賴性存在，而肌肉量的增加是否實際影響運動表現的效益也仍未知。因此，還需更多人體研究以探討其效益。

關鍵字

體脂肪 ； 瘦體組織 ； 肌力

並列摘要

Conjugated linoleic acid (CLA), a commonly used ingredient in weight loss products, is a nutritional supplement claimed to prevent obesity. Different isomers, dosage, and supplementation time of the products, as well as the exercise program can influence its efficacy on body fat mass and lean body mass. The majority of the studies conducted by using CLA mixtures that contained approximately equal amounts of trans-10, cis-12 (t10c12) and cis-9, trans-11 (c9t11) isomers aimed to correct body composition and blood lipid profile. A dose of 3.4 g/ day of CLA was reported as a safe dose for healthy men. However, no dose-response of CLA on human fat mass was observed, and it has not been established whether CLA supplement can increase muscle mass when use in conjunction with exercise training program. More studies would be needed before conclusions can be made. This paper reviews the current knowledge on the mechanism and effect of CLA on body composition, blood lipids and exercise performance.

並列關鍵字

body fat mass ； lean body mass ； muscle strength

參考文獻

Benito, P.,Nelson, G. J.,Kelley, D. S.,Bartolini, G.,Schmidt, P. C.,Simon, V.(2001).The effect of conjugated linoleic acid on plasma lipoproteins and tissue fatty acid composition in humans.Lipids.36(3),229-236.

Berven, G.,Bye, A.,Hals, O.,Blankson, H.,Fagertun, H.,Thom, E.(2000).Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers.European Journal of Lipid Science and Technology.102(7),455-462.

Bhattacharya, A.,Banu, J.,Rahman, M.,Causey, J.,Fernandes, G.(2006).Biological effects of conjugated linoleic acids in health and disease.The Journal of Nutritional Biochemistry.17(12),789-810.

Blankson, H.,Stakkestad, J. A.,Fagertun, H.,Thom, E.,Wadstein, J.,Gudmundsen, O.(2000).Conjugated linoleic acid reduces body fat mass in overweight and obese humans.The Journal of Nutrition.130(12),2943-2948.

Brown, J. M.,Boysen, M. S.,Jensen, S. S.,Morrison, R. F.,Storkson, J.,Lea-Currie, R.(2003).Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes.The Journal of Lipid Research.44(7),1287-1300.