Collaboration between nurses and physicians is essential for successful teamwork and clinical operation. Excellent cooperation and effective communication between nurses and physicians can benefit patient care outcomes, such as a decrease of length of patient hospital stay, a lower rate of patient re-admission and mortality in ICU. Moreover, it can further improve the quality of patient care and control of medical expenses. A poor relationship between nurses and physicians not only caused conflict and tension, but also impacted patient safety and nurses' satisfaction of job and staff retention. Due to above concerns, this article collected lectures with a focus on collaboration- related concept, factors impacting collaboration between nurses and physicians, assessment tools for relationship between nurses and physicians, and studies regarding the correlation between the relationship of nurses and physicians and patient care outcomes. Furthermore, the article addressed some strategies and suggestions toenhancing cooperation and mutual respect between health care professionals and physicians for the purpose of safe patient care. While the leaders of health care organizations are reflecting and planning for the improvement in collaboration between nurses and physicians, these strategies and suggestions may serve as a reference.