A 51-year-old male patient had ectopic hyperparathyroidism and concomitant left goiter. The left goiter extended to the anterior and posterior mediastinum. These endocrine and anatomic conditions induced hypertension, headache, dyspnea, hypercalcemia, and ureteral stone. He also had bilateral huge hydroceles. Initially, the ectopic hyperparathyroidism was ignored that he underwent complete resection of the extending goiter via a partial sternotomy. Bilateral hydrocelectomies were also concomitantly performed. The initially neglected ectopic hyperparathyroidism was treated using thoracoscopic parathyroidectomy 10 months later. All symptoms were relieved and serum calcium was at a normal level following these surgeries and extracorporeal shock wave lithotripsy.