Stroke is the one of the comment neurological diseases. There are different types of Stroke such as ischemic or hemorrhage stroke. Strokes of ischemic and hemorrhage have different causes and effects in patients, it leads to patients disability or death. Most of Patients and caregivers have stress because of disability caused by stroke. The life change includes daily care, occupation, and economy. Stoke treatment in clinic focus on medication and neurological surgery, also some of combination with rehabilitation or Chinese medication. The recent advances in stem cell therapy, with pre-clinical references and clinical trials, we can see future prospects for stem cell therapy in treating stoke.