Acute leukemia associated pulmonary complications, such as hemoptysis, infection and pulmonary hemorrhage, are all potentially life-threatening. Although pulmonary complications in patients with acute leukemia are common, they pose a diagnostic and therapeutic dilemma when they occur as the initial presentation. We present a 32 year-old man with acute lymphoblasitic leukemia (ALL) who had fever, pulmonary infiltration, hemoptysis, pending respiratory failure, and a low blast cell count at presentation. The patient was treated with chemotherapy and resulted in rapid resolution of the chest pulmonary infiltration, as well desaturation. Emergency physicians should be alert to leukemic pulmonary infiltrates as a first manifestation of ALL, since early initiation of steroids and chemotherapy may obviate the need for advanced airway management and mechanical ventilation.