- 期刊
Aeromonas Hydrophila Infection: 6-Year Experience and Literature Review
產氣單胞桿菌屬(Aeromonas Hydrophila)感染：六年經驗和文獻瀏覽
摘要
目的：產氣單胞桿菌屬細菌並不是常見的感染病症，但卻可以造成嚴重致命的感染。 方法：從連續六年間（2003/1/1至2008/12/31）在台東馬偕醫院被診斷出產氣單胞桿菌屬菌血症的48位病患中分析其人口統計學，臨床表徵，實驗檢驗數據及最終結果。 結果：共39位男性和9位女性病患。在這群48位病人其中，有36位是單一菌種感染而其餘12位是多重細菌感染。病患最常見的症狀為發燒(43/48, 90%)黃疸(28/48, 58%)及腹痛(25/48, 52%)。此外48位病患本身病史上，擁有肝硬化者(27/48, 56%)，惡性腫瘤者(7/48, 15%)。實驗研究上產氣單胞桿菌屬對抗生素的有效敏感測試如下Gentamycin(100%)，Quinolone(98%)，Chloramphenicol(98%)，Cefuroxime(94%)，Cefotaxime(94%)。對Ampicillin抗藥性是(98%)。 結論：產氣單胞桿菌屬細菌好發於肝硬化或是惡性腫瘤的病人身上，而且預後並不好。總粗死亡率是15/48，31%。貧血，白血球增多，腎功能受損是獨立重要的死亡危險因子。
並列摘要
Background: While uncommon, Aeromonas hydrophila bacteremia can be fatal. Method: From January 1, 2003 to December 31, 2008, 48 patients (39 males, 9 females) diagnosed with A. hydrophila bacteremia were admitted to Mackay Memorial Hospital in Taitung. Patient demographic data, clinical features, laboratory data, and outcomes were retrospectively analyzed. Result: Of the 48 cases of A. hydrophila bacteremia, 36 were monomicrobial and 12 were polymicrobial infections. The most common symptoms were fever (43/48, 90%), jaundice (28/48, 58%), and abdomen pain (25/48, 52%). Underlying diseases included liver cirrhosis (27/48, 56%), and malignancy (7/48, 15%). In vitro, A. hydrophila was generally susceptible to gentamycin (100%), quinolones (98%), chloramphenicol (98%), cefuroxime (94%), and cefotaxime (94%) and resistant to ampicillin (98%). A. hydrophila bacteremia usually occurred in patients with liver cirrhosis or malignancy and heralded a poor prognosis. The overall crude fatality rate was (15/48, 31%). Anemia, leukocytosis, and impaired renal function were independent significant risk factors of death. Conclusion: A. hydrophila, although not common, can cause notable rates of morbidity and mortality among immunocompetent and immunocompromised persons. It is important to have a high index of suspicion and increase awareness of A. hydrophila infection at initial presentation. Prompt diagnosis and early treatment with adequate antibiotics are vital.