Patients with central nervous system (CNS) lesions usually lack mobility, which result in neuromuscular changes. The common clinical sign of CNS lesion is hypertonia. Spasticity (velocity dependent tonic reflex hyper-excitability) is considered as one component of hypertonia. Traditionally, hypertonia is believed to be due to disinhibiti on of descending excitatory influence on spinal motoneurons, which in turn induces tonic stretch reflex hyper-excitability. However, over the last two decades, researchers have found that non-reflex factors also contribute significantly to hypertonia. Therefore, the reflex and non-reflex components are included in hypertonia. The reflex component is related to the stretch reflex, and the non-reflex component is related to the viscoelastic property of muscles, tendons, and ligaments. This article summarises findings of recent studies, and provides the clinicians with the mechanisms of hypertonia. This will assist the therapists to select the appropriate intervention strategies for patients with central nervous lesions.