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肥胖型肌少症:定義、機制與運動訓練的成效

Sarcopenic Obesity: Definition, Mechanism, and Effects of Exercise Training

摘要


肥胖型肌少症(sarcopenic obesity)是指隨年齡增長,肌肉質量流失伴隨脂肪增加的情況。其盛行率與肌少症(sarcopenia)或肥胖一樣,都會隨著年齡的增加而增加。肥胖型肌少症者自評為身體失能之勝算比(odds ratio)較正常人、肌少症及肥胖高出數倍。隨著人口結構老化,此問題日漸受到重視,本文簡介肥胖型肌少症的定義、可能機轉以及與身體功能和失能的關係。由於尚無針對肥胖型肌少症運動訓練介入成效之文獻報導,故僅能回顧一些肥胖老人和一篇肌少症運動訓練效果的研究。未來需更多高品質長期追蹤的研究證實運動對肥胖型肌少症運動訓練的療效。

並列摘要


Sarcopenic obesity refers to age-related loss of muscle mass and coincident increases in fat mass. The prevalence increases with aging, just like sarcopenia and obesity. The odds ratio of self-evaluated physical disability for those with sarcopenic obesity was several times higher than that of normal subjects, or those with sarcopenia or obesity. We reviewed the current definitions, possible mechanism, and the association with physical function or disability. Since no literature has been found regarding the effects of exercise training intervention for the elders with sarcopenic obesity, we reviewed some studies for the obese elders and one study for the sarcopenic elders in an attempt to provide some management clues for this subpopulation. More investigations of high quality with long-term follow-up are needed to clarify the efficacy of exercise intervention for the elders with sarcopenic obesity.

參考文獻


Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39:412-23.
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Zamboni M, Mazzali G, Fantin F, Rossi A, Di Francesco V. Sarcopenic obesity: A new category of obesity in the elderly. Nutr Metab Cardiovasc Dis 2008;18:388-95.

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