- 期刊
【論文摘要】Effects of Preconditioning Exercise on Blood Pressure and Brain Inflammatory Responses in Rats With Obstructive Sleep Apnea
【論文摘要】運動預防大鼠在阻塞性睡眠呼吸中止症所引起之血壓和腦部發炎反應的效果
摘要
Background and Purpose: Obstructive sleep apnea (OSA) is a common condition marked by repeated upper airway collapse during sleep, leading to hypertension and neurocognitive disorders. This study uses a rat model to investigate the effects of preconditioning moderate-intensity aerobic exercise on brain inflammatory cytokines and blood pressure in OSA. The purpose is to provide recommendations for the preventive mechanisms of OSA. Methods: Six male Sprague-Dawley rats (weight 250-300g) were divided into Control group (CON) n = 2, Obstructive sleep apnea group (OSA) n = 2 and Obstructive sleep apnea combine exercise group (OSA + EXE) n = 2. The total duration of the experiment for the CON and OSA groups was 7 days, with measurements on the eighth day. The OSA + EXE group Executed a 3-week exercise training and intermittent hypoxia exposure. Measurements included blood pressure and brain tissue (substantia nigra) inflammatory cytokines. Results were significant at p < 0.05. Results: The mean arterial pressure of the OSA group was higher than that of the CON group (p = 0.001) and the OSA + EXE group (p = 0.001). Diastolic pressure was also higher in the OSA group compared to the CON group (p = 0.002) and OSA + EXE group (p = 0.004). The OSA group had lower body weight than the CON group (p = 0.017), with no significant difference compared to the OSA + EXE group (p = 0.7). Pro-inflammatory cytokines Tumor Necrosis Factor-α (TNF-α) and Interleukin-6 (IL-6), and anti-inflammatory cytokine Interleukin-10 (IL-10), were higher in the OSA group than the CON group, while the OSA + EXE group showed higher TNF-α and lower IL-6 and IL-10 compared to the OSA group, with no significant differences (p > 0.05). Conclusions: OSA leads to increased blood pressure, elevated levels of pro-inflammatory and anti-inflammatory cytokines in the brain. Preconditioning exercise training conducted before the onset of OSA results in reduced blood pressure and decreased levels of pro-inflammatory and anti-inflammatory cytokines in the brain compared to the OSA group. Clinical Relevance: Preconditioning aerobic exercise training before the onset of OSA can be suggested as a preventive strategy for hypertension symptoms and central nervous system inflammatory responses caused by OSA.