Acupuncture is one of most popular complementary therapies in Asia. Pneumothorax following acupuncture is one of the serious complications, but fatal consequences are rare to date. We report a 61-year-old male who suffered from right-side tension pneumothorax after acupuncture along the paraspinal region on the upper back for his chronic neck and back pain. Bilateral alveolar infiltration progressed subsequent to chest intubation for emergent decompression. Acute respiratory distress syndrome (ARDS) developed, and the patient died due to severe hypoxemia within twenty-four hours after acupuncture.