- 期刊
不同鋅化合物對糖尿病鼠的降血糖效果
The Anti-Hyperglycemic Effects of Various Zinc Complexes in Streptozotocin-Induced Diabetic Mice
摘要
鋅除了可影響胰島素的生成及活性外，鋅本身也有類胰島素的作用。鋅補充有降低糖尿病高血糖的效果，不過長期大劑量的鋅補充有可能造成銅缺乏性貧血等現象。本試驗利用鏈佐黴素所誘發的糖尿病小鼠，探討在使用低劑量的不同鋅化合物處理後（硫酸鋅、氯化鋅、葡萄糖酸鋅、葡萄糖酸甘胺酸鋅、麥芽醇鋅），進行比較此些鋅化合物之抗糖尿病高血糖效果的差異。離體試驗結果顯示在使用相同處理濃度下(1mM)，鋅促進脂肪細胞脂質合成作用的效果以麥芽醇鋅最好（麥芽醇鋅＞葡萄糖酸甘胺酸鋅＞葡萄糖酸鋅＝硫酸鋅＝氯化鋅）。活體試驗上，糖尿病小鼠在給予口服相同劑量(15mg/kg/d)的鋅補充處理四週後，禁食血糖降低的程度也以麥芽醇鋅的效果最好（麥芽醇鋅＞葡萄糖酸甘胺酸鋅＞葡萄糖酸鋅＞硫酸鋅＝氯化鋅）。本試驗的結果顯示適當補充高生體利用率的鋅化合物可能有助及更合適於糖尿病高血糖的輔助治療。
並列摘要
Zinc is known to participate in the synthesis and activity of insulin. In addition, zinc itself has an insulinlike action. Zinc supplementation has also been found to markedly ameliorate diabetic hyperglycemia. However, the doses effectively reducing hyperglycemia are usually high and may result in certain harmful side effects, such as copper-deficient anemia. Thus, the effect of a zinc complex of lower dosage but higher bioavailability in the management of diabetic hyperglycmia warrants evaluation. This study was undertaken to compare the efficiency on reducing diabetic hyperglycemia of various zinc complexes (zinc sulfate, zinc chloride, zinc gluconate, zinc gluconate glycine, zinc maltol) in streptozotocin-induced diabetic mice. The results in in vitro study showed that, by giving the same dosage (1 mM), zinc-induced lipogenesis was highest in fat cells treated with zinc maltol than those of the other zinc complexes (maltol＞glycine＞gluconate=chloride=sulfate). In in vivo study, the results indicated that the improvement in fasting glycemia was most eminent in diabetic mice receiving oral zinc maltol administration (15 mg/kg/d; maltol＞glycine＞gluconate＞chloride=sulfate). The results of this study suggest the supplementation of high bioavailability zinc complex may be beneficial for and applicable to the management of diabetic hyperglycemia.