This study simulated the smoke environment of the fire site and set up a high-power negative-air-ion (NAI) smoke removal array. By measuring the number of NAIs and the change of PM2.5 particle concentration in the smoke, the unit efficiency of the smoke removal array to remove PM2.5 suspended particles was calculated. This study used the residential stair hall as the experimental site to detect the difference in the degree of NAI diffusion with or without wind assistance to design an NAI smoke-removal-assisted escape system for indoor smoke environments. It is expected to assist rescuers and escape people in obtaining cleaner air and clearer sight in a smoky environment, increasing the golden escape time.