- 期刊
Cardiotoxicity in Imipramine Intoxication: Report of One Case
Imipramine意外中毒：一病例報告
摘要
Imipramine是最常引起致命性藥物中毒的三環抗憂鬱劑。我們報告一例十五月大的男童因爲誤食Imipramine中毒而導致全身性抽搐、昏厥及疑懼似心室頻脈發作。其連續心電圖所顯示PR、QRS、QTc等傳導時間明顯延長的變化提醒我們將此藥物中毒列入鑑別診斷。在經過活性碳胃部灌洗及使用碳酸氫鈉鹵僉化血液後，上述心電圖變化在12小時內慢慢回複正常且病童神智恢複清醒再也沒有抽搐發作。Imipramine血中濃度值經檢測高達1.389ng/ml。病童癒後良好並無留下任何神經學後遺症。
並列摘要
Imipramine is the most commonly prescribed tricyclic antidepressant of acute life threatening self- poisoning. We report a 15-month-old boy of accidental poisoning with imipramine, who developed generalized tonic-clonic convulsions and drug-related cardiac conduction abnormalities with PR prolongation, QRS widening, and QTc lengthening. The patients imipramine level was 1389ng/ml. The rapid resolution of intraventricular conduction delay and normalization of the QRS-T complexes after gastric lavage, installation of activated charcoal and alkalinization of the blood strongly implicates imipramine intoxication in the etiology of the cardiotoxicity. The patient made a full recovery without neurological sequelae.