- 期刊
Household Helicobacter Pylon Antibody Survey in Children with Upper Gastrointestinal Symptoms
對於有上消化道症狀的兒童檢查其家人幽門螺旋桿菌抗體盛行之狀況
摘要
本研究主要是評估有腸胃道症狀的病童，依據幽門螺旋桿菌感染與否分組，比較其家屬幽門螺旋桿菌抗體陽性率差異，籍以觀察家屬群聚感染的情況，希望能進一步 解幽門螺旋桿菌的傳灑途逕。從1998年8月開始到2000年3月我們總共檢查了112個腸胃道症狀的兒童，其中男童59人、女童53人，平均年齡11.4±1.5歲，範圍從0.9歲到15.3歲。他們全部都接受胃鏡檢查，並且採取胃黏膜做細菌培養確立診斷，病童父母和兄弟姐妹則接受抽血檢查，檢驗抗體的存在。結果顯示有51.7%有症狀病童有幽門螺旋桿菌感染。比較兩組病童的父親（陽性組80.7%對附性組79.3%，P值1.000）；母親（陽性組84.7%對陰性組70.1%，P值0.093）及兄弟姐妹（陽性組47.0%對陰性組23.0%，P值0.259）的血清幽門螺旋桿菌抗體並無明顯差異仔在。結論：依據我們的資料顯示，不論病童是否有幽門螺旋桿菌感染，他們的家屬幽門螺旋桿菌抗體陽性率並無顯著差異。推論可能因爲我們的血清樣本主要來自有症狀的病童家屬，可能家屬本身的幽門螺旋桿菌感染率就高於一般家庭。所以遮掩了家屬群聚感染的差異性，我們需要進一步研究才能釐清這個問題。
並列摘要
The aim of this study was to evaluate the family clustering in symptomatic children and to better understand possible transmission routes of Helicobacter pylon (H. pylon) infection. From September 1998 to March 2000, totally 112 children with upper gastrointestinal symptoms (M:F=59:53, mean age 11.4±1.5 years, range from 0.9 to 15.3 years old) were enrolled. All of them underwent upper endoscopic examination. Their parents and siblings were recruited to check the serum anti-H. pylori. The results showed 58 of 112 (51.7%) children were infected with H. pylon, while the remaining 54 children were not. To compare the H. pylon (+) and H. pylon (-) groups, we found differences in anti-H. pylori seropositive rates between their fathers (80.7% vs. 79.3%, p=l.000), mothers (84.7% vs. 70.1%, p=0.093) and siblings (47.0% vs. 23.0%, p=0.259) were not statistically significant. In conclusion, the H. pylori seroprevalences between the families of H. pylon-infected and non-infected children were not different. A relatively high H. pylon seroprevalence in the background population may mask the difference. We might need a revised seroepidemiologic study in the future to further clarify this issue.