- 期刊
Nasopharyngeal Carcinoma in Children: A Single Institution's Experience
小兒鼻咽癌：單一醫院之經驗
摘要
鼻咽癌在小孩子相當罕見。從1992年到2005年共有八位男孩及兩位女孩於本院治療。年紀為十二歲至十七歲，病理組織均為未分化型。十位病童中若依腫瘤侵犯情形來分，一位為T2，五位為T3，四位為T4。淋巴結方面，則有八位病童有淋巴結的轉移，其中有六位雙側均有，有四位其淋巴結至少有一側大於六公分。發病時的主要症狀為為頸部腫塊，鼻子或耳朵症狀，腦神經麻痺及頭痛。在治療方面，有四位病童僅接受放射線治療，有六位則同時接受放射線及化學治療，平均放射線劑量為七千二百分格雷。有兩位病童發生遠處復發而分別在一年及四個月後死亡。平均追蹤三十個月，無事件存活率及整體存活率為百分之七十及七十五。雖然整體個案數不多，但似乎即使已達第三期或四期，仍有機會存活。可是必須注意治療後可能發生的問題。
並列摘要
Nasopharyngeal carcinoma is a very rare disease of children. Between 1992 and 2005, 8 male and 2 female patients [ages ranging from 12 to 17 years,] were treated in our institution. The histopathologies were all undifferentiated type (WHO Type Ⅲ). Of the ten patients, one was T2, five were T3, and four were T4, respectively (TNM system of the American Joint Committee for Cancer Staging). Eight patients had node metastases, 6/8 had bilateral and 4/8 had nodes larger than 6 cm. The main symptoms at diagnosis were neck mass followed by nasal, aural symptoms, cranial nerve palsy and headache. Four patients received radiotherapy only, while six patients received cisplatin-based concomitant chemoradiotherapy. The mean irradiation doses to the primary sites were 7200 cGy. Two patients developed early systemic relapse and died one year and 4 months, respectively, after relapse. After a median follow-up of 30 months, the event-free survival and overall survival were 70% and 75%, respectively. Although the sample size was small, it seemed that the patients had a good chance of survival in spite of advanced stage. However, late morbidity was a concern.