- 期刊
Permeation of Drugs through Polymeric Membranes with and without Swelling Gradient
藥物透過有膨潤梯度薄膜之行為分析
摘要
本研究發展一套方法來計算在有膨潤梯度下藥物透過高分子膜的擴散係數，並將計算結果與實驗數據相比較，評估所發展方法的準確性。實驗中所使用的膜材為PU及EVA，所使用的藥物是benzocaine，而所採用的膨潤劑是乙醇。要計算有膨潤梯度下benzocaine在膜中的擴散係數，必須先知道乙醇(膨潤劑)在膜中的濃度分布，及均勻膨潤下擴散係數與乙醇濃度(膨潤度)間的關係。均勻膨潤下benzocaine之擴散係數與乙醇濃度及膨潤度間的關係，可由實驗求得；乙醇在膜中的濃度分布則可經由量測不同乙醇濃度下乙醇之透膜通量求得。根據上述的數據，可計算出有膨潤梯度下，benzocaine在PU膜及EVA膜中的擴散係數，計算之結果與實驗量測值十分吻合，顯現出計算方法的可靠性。
並列摘要
A procedure was developed in the present work to calculate the effective diffusivity of drugs through polymeric membranes subject to swelling gradient. Experiments were also performed to examine the accuracy of the calculation procedure. The membranes used were dense polyurethane and poly(ethylene-co-vinylacetate) membranes, the model drug was benzocaine, and the swelling agent was ethanol. To calculate the effective diffusivity of benzocaine, it requires knowing the dependence of benzocaine diffusivity on ethanol concentration and the ethanol concentration profile across membrane. Experiments of homogeneous swelling were carried out to determine the relationship between benzocaine diffusivity and ethanol concentration. In addition, by measuring the ethanol fluxes corresponding to different ethanol concentrations in the donor cell, the ethanol concentration profile across membrane can be determined. With the above information, the effective diffusivity of benzocaine through membranes with swelling gradient can be calculated. Experiments were also carried out to measure the effective benzocaine diffusivity. Agreement between the calculated and experimental results was obtained, indicating that the proposed calculation procedure is quite reliable.