- 期刊
Fibroblast Growth Factor 21 Predicts Type 2 Diabetes in Taiwanese
並列摘要
Aim: The prevalence of type 2 diabetes mellitus is rising worldwide especial in Asian. Liver-derived fibroblast growth factor (FGF)-21 interplay glucose and lipid metabolism. The aim of this study was to analyze the predictive value of FGF-21 in Taiwanese T2DM.Materials and Methods: Eighty healthy control and two hundred eleven type 2 diabetes participants are enrolled into this study. After at least 8-hour fasting, blood sampling has been done and sent to the laboratory of Vascular & Genomic Center, Changhua Christian Hospital for advanced experimental tests. Participant's anthropometric, biochemical and hormonal data of T2DM and healthy control groups are collected.Results: The parameter including age, body mass index (BMI), BUN, Cr, TG, blood fasting glucose, HbA1c, insulin and FGF21 concentrations were significantly (p ＜0.05) higher in T2DM group compared to healthy subjects. On the contrary, HDL levels were significantly lower in diabetes group. FGF21 levels correlated positively with age, BMI, BUN, Cr, SBP, LDL and TG but negatively with HDL cholesterol. In a general linear regression analysis, TG (beta = 0.244, P＜0.01), Cr (beta =328.8, p＜0.01) were independently related to plasma FGF21 levels. An AUC of 0.723 with FGF-21 and the range from lower to upper is 0.656 to 0.79. The best cut value about prediction diabetes or not is 322.9 pg/mL.Conclusion: FGF-21 is an independent predictor of the Taiwanese T2DM. In combination with existing experimental data, our data may suggest a state of FGF-21 resistance preceding to diabetes. FGF21 interplay and regulate the energy metabolisms of lipids and carbohydrates which is a good candidate to detect the pathophysiological mechanism of diabetes and its related complications.