- 期刊
Genetic Analysis of Ossification of the Posterior Longitudinal Ligament-A Case Report
摘要
Ossification of the posterior longitudinal ligament (OPLL) is a rare but serious condition of the cervical spine characterized by abnormal calcification of the posterior longitudinal ligament. While many individuals with cervical OPLL may not experience symptoms, this condition may result in degenerative myelopathy and eventually lead to spinal cord compression. This study reports the first case of OPLL with spinal cord injury in Taiwan for which genetic analysis was conducted. The patient presented with pain in several areas of the body after a traffic accident. Cervical (C) magnetic resonance imaging (MRI) revealed OPLL from C2 to C5. Genetic analysis revealed four susceptibility single nucleotide polymorphisms (SNPs), including rs1979679, rs11045000, rs13279799, and rs374810, which have been shown to be associated with OPLL in previous studies. Numerous studies have identified specific genes and comorbidities associated with OPLL. Therefore, it is important for clinicians to be aware of these genetic factors when evaluating patients at high risk of developing cervical OPLL.