Objective: To evaluate the prevention strategies for adverse drug reactions during CT contrast enhanced scan. Methods: analysis of the nursing experiences to prevent adverse reactions among 1401 cases of patients with enhanced CT scan. Results: Taken appropriate care interventions, the adverse reaction rate was 0.785%, which showed to be lower than the 1-2.5% described in literature. No serious adverse events happened. Conclusion: The strict implementation of the care process during enhanced CT angiography can prevent adverse reactions of contrast medicine effectively and make patients more safely and examination smoothly.