- 期刊
犬黏液型脂肪肉瘤之病理學特徵：三個病例報告
Histopathological Characteristics of Canine Myxoid Liposarcoma: A Report of Three Cases
摘要
兩隻混種犬（一公一母）及一隻羅威那母犬，年齡皆為十歲，分別因為於右下顎、右髖部及頸部背面之皮下軟組織，出現明顯腫脹的腫塊，經外科手術切除腫塊後送；請團立台灣大學附設動物醫院進行病理學檢查。肉眼病理學檢查，腫瘤團塊外圍無結締組織被膜包被，切面為灰白色，局部區域呈暗紅色，大部組織觸感軟但部分組織微硬。三例共同的組織病理特徵為腫瘤實質區域主要由大量增生的脂肪母細胞混雜成熟脂肪細胞及豐富黏液樣基質所構成。在高倍視野下觀察，腫瘤細胞為梭形、星狀與多角性，而且細胞與細胞聞界限不明顯，細胞質含有圓形大小不的空泡及大量黏液樣物質分佈於腫瘤細胞間的基質，細胞核為圓形、卵圓形及多形性，且顯著大小不一，部分纖維組織間隔（fibrous septa）伸入腫瘤實質區，將腫瘤隔成不規則的小葉，有絲分裂相少見，血管分佈由少量到豐富均有。三例腫瘤組織經Alcian blue/periodic acid-Schiff（AB-PAS）及Oil red O組織化學染色，均呈現陽性，顯示腫瘤細胞質含有脂質與豐富的黏液蛋白成份。依據上述組織病理學特徵及組織化學染色結果，證實為黏液型脂肪肉瘤。
並列摘要
Three dogs, one male and two females, aging 10 years old, two mixed breed dogs and one Rottweiler were referred for further examination with a history of swelling on the right jaw, right hip, and dorsal neck, respectively. On physical examination, the masses showed swelling and soft or firmness by palpation. The surgically removed masses were submitted for pathological evaluation at National Taiwan University Veterinary Hospital (NTUVH). Macroscopically, the masses were soft or firm from areas to areas, grey-white to dark reddish on cut surface. Histopathological examination, the masses with or without encapsulation are chiefly composed of spindle, satellite to polygonal, mature adipocytes intermixed with areas of more primitive cells and abundant basophilic, myxoid matrix. The nuclei are round, oval to pleomorphic. Alcian blue/periodic acid-Schiff (AB-PAS) and Oil red O staining demonstrate abundant lipid and myxoid substance in the cytoplasm of the neoplastic cells and matrix. On the basis of the histopathological and histochemical findings, myxoid liposarcomas were diagnosed.