The use of nursing practitioners has been one of the important policies initiated by the Department of Health Bureau in recent years. This approach should improve nursing professional competence and promote quality of care. The purpose of this study was to understand the perceptions held by hospital nursing managers about nurse practitioners; this was carried out using focus groups. In total, 22 hospital nursing managers from the northern, central, and southern areas of Taiwan were invited to take part in the study. Seven of the nursing managers came from medical center hospitals, seven came from area hospitals, and eight came from local area hospitals. The interview contents were collected verbatim and then analyzed. The results fell into two categories; the first was the managers' opinions of current situation with respect to nurse practitioners in Taiwan and the second was the managers’ future expectations of nurse practitioners in Taiwan. The former category could be divided into five themes: doctor shortage and nurse substitute, professional and personal development, variable names for the same job, managerial problems caused by a loss of identity, and the designation of responsibility. The latter category had two themes: expectation versus injury and the hope of protection from legal problems. The results of this research will provide a reference when establishing the job description of and setting the regulations for nursing practitioners.