失智症與代謝症候群的關連性及其防治策略

目的：探討失智症與代謝症候群的關連性及其防治策略。方法：主要係透過失智症的介紹、失智症與代謝症候群的關連性、運動與增加身體活動量對失智症及代謝症候群防治策略上的重要性和營養對失智症及代謝症候群防治策略上的重要性等不同面向之文獻搜集來加以討論，期望提供業務主管機構及後續研究者能進一步建構適合我國失智症防治方法，以提昇我國失智症預防性功能。結語：失智症中以阿茲海默症及血管型失智症所占的比例最高，代謝症候群和這兩種失智症的病理機轉都有密切的關連性，以代謝症候群中之各個單獨的因子來看，空腹血糖越高者，以後得到失智症的危險性也越高；而代謝症候群除了藥物治療外，運動與飲食控制是不可或缺的兩大方法。建議：每週實施3次中等強度的有氧運動與阻力運動，以及多吃蔬果、豆類、穀類、魚，少吃高油脂、高糖類的食物，來達到降低代謝性疾病及預防失智症的發生。

關鍵字

高血壓；高血糖；高血脂；肥胖

並列摘要

Investigate the correlations between dementia and metabolic syndrome, and relevant preventive strategies. Mainly involves literature review and discussion on the introduction of dementia, the correlations between dementia and metabolic syndrome, the importance of sports and increased physical activities as a preventive strategy for dementia and metabolic syndrome, and the importance of nutrition as a preventive strategy for dementia and metabolic syndrome. The aim is to provide competent authorities and subsequent researchers with information intending to establish measures for preventing and treating dementia and to improve the effectiveness of dementia prevention in Taiwan. Alzheimer's disease and vascular dementia would be the most prevalent forms of dementia. The pathogenesis of both forms of dementia would be closely related to metabolic syndrome. When reviewing single factors of metabolic syndrome, individuals with higher blood sugar levels when fasted are more likely to suffer from dementia. In addition to pharmaceuticals, exercise and dietary management would be the other two major treatment methods. To reduce the incidence of metabolic diseases and prevent dementia, individuals should be provided with 3 sessions of aerobic and resistance exercises of medium intensity every week as well as a diet that is rich in vegetables, legumes, cereals, and fish while reducing the intake of foods with high fats or sugars.