MR imaging has become a powerful clinical tool for evaluation of brain anatomy. Its application has recently expanded into evaluation of brain function via assessment of a number of functional or metabolic parameters. MR perfusion imaging refers to several recently developed techniques used to noninvasively measure cerebral perfusion via assessment of various hemodynamic measurements such as cerebral blood volume, cerebral blood flow, mean transit time, and time to peak. These techniques have great potential in the diagnosis and treatment of patients with cerebrovascular disease and other brain disorders and assessment of treatment effect in patient with acute ischemic stroke. The purpose of this article is to provide an understanding of basic techniques and applications of MR perfusion imaging and share our experience.