- 期刊
利用電腦斷層計算骨小樑骨質分數之骨小樑結構及品質評估
Bone Quality Evaluation Using a Trabecular Bone Score from Computed Tomography Images
摘要
現今臨床上骨質密度的評估主以使用雙能量X光吸收術（dual-energy x-ray absorptiometry, DEXA），掃描受檢者後獲得平面骨質密度（areal bone mineral density, aBMD）為主要方法，但DEXA在使用上會受到受檢者的體厚、腹部脂肪含量與骨骼結構的影響，使結果有誤差的存在。本研究利用CT影像分析骨骼內結構，並計算aBMD及骨小樑分數（trabecular bone score, TBS），找出參數間之關聯性，以及與年齡間的相關性，並且希望透過TBS參數在臨床上來有效評估人體的骨骼強度。本研究共收集53位患者影像，為別為女性25位與男性28位，平均年齡分別為49.92歲和50.5歲，經確認過沒有骨癌、骨骼代謝疾病以及脊椎壓迫性骨折相關病史之女性及男性腹部電腦斷層影像，先於影像中定出腰椎有興趣區域後，接著以腰椎影像中的灰階均方差計算TBS，並分析其與aBMD間的趨勢性。根據實驗的結果顯示TBS與aBMD皆會隨著年齡增加呈現下降的趨勢，aBMD與TBS呈現正相關的現象，在統計分析亦顯示顯著的差異。因此我們認為，TBS 對人體骨骼強度的評估是有幫助的，而且是一個有效的指標。
並列摘要
Bone mineral density (BMD) is critical to the bone strength of patients. Dual-energy x-ray absorptiometry (DEXA) is a common method for measuring the BMD of patients. However, the BMD values from DEXA are strongly influenced by body thickness, abdominal fat content, and bone structure. In this study, the relationships between areal bone mineral density (aBMD) and trabecular bone score (TBS) were evaluated using computed tomography (CT) images. Abdominal CT images were collected from 53 patients who have been confirmed free from bone diseases. This study selected 25 women and 28 men. Their mean age was 49.92 and 50.5 years. The aBMD and TBS from the variogram were calculated from each lumbar spine. According to the results of the regression analysis, TBS and aBMD are inversely proportional to age. The TBS is proportional to the aBMD values. Therefore, the TBS calculated from projection images is a useful index for evaluating bone quality.