Tissue perfusion altered-renal function is a nursing care problem often seen clinically. It is often mistaken as a minor problem or renal dysfunction, but as a matter of fact, tissue perfusion altered-renal function affects all bodily function and if early diagnosis is not made in time to allow for immediate monitoring and treatment, the result will be irreversible renal damage. The question of ”when should nursing diagnosis intervene?” has always puzzled clinic nurses and although a diagnosis has been adopted, it lacks clear definition. As a result, this paper attempts to explore the application of clinic diagnosis based on literature review to allow clinic nurses to understand and think of the cause of nursing care and to provide high quality and professional care to patients with accuracy and confidence.