- 期刊
Liver Biopsy Pathology in Human Immunodeficiency Virus Infection
人類免疫缺乏病毒感染病人肝生檢之病理
摘要
目的：人類免疫不全病毒(HIV)感染患者臨床上常見肝功能異常現象，為探討此肝功能異常在臨床及病理所代表之意義。方法：本院從民國七十九年十一月至八十八年四月，共有四十四位HIV患者（四十二男，兩女，平均年齡三十七歲），因臨床上懷疑肝臟疾病接受肝生檢檢查。結果：其中有82%（三十六位）患者有肝實質變化並且有73%（三十二位）的診斷率。肉芽腫性肝炎是其中最主要的發現（43%，十九位）、其次是無特異性變化（18%，八位）、慢性生肝炎（16%，七位）、特定感染（13%，六位）、脂肪性變化（11%，五位）。其中無任何患者因接受肝生檢而死亡或致重大併發症。結論：肝生檢對 HIV 感染患者是安全且診斷率高之臨床步驟。
並列摘要
Background and Purpose: Hepatic dysfunction frequently develops in patients infected with the human immunodeficiency virus (HIV). Method: We report on 44 HIV-infected patients (42 men and 2 women with a mean age of 37 years) who underwent percutaneous liver biopsies for the assessment of clinical or biochemical evidence of liver injury from November 1990 to April 1999. Results: Significant abnormalities were detected in 82% (36/44) of patients, and a diagnosis was proven in 73% (32/44). The most-common findings were granulomatous hepatitis (GH) (19/44, 43%), non-specific changes (8/44, 18%), chronic hepatitis (7/44, 16%), specific infections (6/44, 13%), and fatty metamorphosis (5/44, 11%). No procedure-related deaths nor major complications occurred. Conclusion: A liver biopsy is a safe and accurate method for detecting underlying disease in HIV-infected patients.