Background and purpose: Mesenteric venous thrombosis is a rare but potentially lethal form of mesenteric ischemia. Its presentation may vary from an entirely asymptomatic clinical entity to intestinal infarction and shock. Methods: A patient with mesenteric venous thrombosis was sent to our hospital because of acute abdominal pain that had developed over a single day. The physical findings and imaging examination suggested peritonitis. Results: An emergency laparotomy revealed bowel infarction due to mesenteric venous thrombosis. Segmental resection of the involved bowel with primary anastomosis was performed and resulted in a rather smooth post-operative course with post-operative heparin administration. Conclusion: In review of the literature, the high index of suspicion of mesenteric venous thrombosis, early diagnosis, early surgical management and perioperative heparin therapy will improve the outcome of this disease.