摘要
目的：在正常情況下，月經來潮必須經由身體內一系列複雜的荷爾蒙相互作用。簡而言之，首先是下視丘分泌促性腺素(GnRH)來刺激腦下垂體。腦下垂體被刺激後會分泌濾泡刺激荷爾蒙(FSH)及黃體化荷爾蒙來調控卵巢的濾泡發育和排卵。卵巢在排卵之前會分泌動情素來刺激子宮內膜增生，在排卵之後除了持續分泌動情素，也會分泌黃體素來穩定子宮內膜。如果沒有懷孕，因為卵巢分泌的動情素及黃體素濃度會降低，導致子宮內膜崩潰，也就是月經來潮。只要身體內這些相關的器官失常或荷爾蒙失調都有可能導致無月經症。方法：在本報告中我們分析了多個因手術或藥物治療後導致的醫原性無月經及不孕症。結論：對於生育年齡的婦女如果須要接受手術或藥物治療時我們應該更加注意如何能保有其生育能力。
並列摘要
Background and Purpose: Normally menstruation involves complex hormonal interactions. Briefly, after the hypothalamus secretes the gonadotropin-releasing hormone (GnRH) in a pulsatile fashion, modulated by neurotransmitters and hormones, the GnRH stimulates a secretion of follicle-stimulating hormone (FSH) and luteinizing (LH) from the pituitary. The FSH and LH promote ovarian follicular development and ovulation. At the beginning of each menstrual cycle, the ovarian follicle secretes estrogen as its normal function, and after ovulation the follicle is converted to a corpus luteum and increases the secretion of progesterone in addition to the secretion of estrogen. Under these hormonal behaviors, the endometrial development changes following the above hormonal effects. If pregnancy does not occur 1 week after ovulation, the secretion of estrogen and progesterone decreases, then the endometrium is necrosed and the withdrawal bleeding begins. If any of the hypothalamic-pituitary-ovarian axis is not functional, menstruation will not occur. We defined iatrogenic amenorrhea as a menstrual disorder due to medical or surgical management. Methods: We analyzed patients who had received medical or surgical treatment which resulted in amenorrhea, then we successfully treated them. Conclusion: Physicians need to be very careful in the treatment of disease and the consideration of fertility preservation when the patient is of reproductive age.