- 期刊
慢性腎臟病導致次發性副甲狀腺機能亢進的治療
Treatment of Secondary Hyperparathyroidism Caused by Chronic Kidney Disease
摘要
慢性腎臟病會造成礦物質及骨頭代謝異常，統稱為腎性骨病變（renal bone disease），可能會出現鈣、磷、副甲狀腺等代謝異常以及缺乏活性維生素D。其中慢性腎衰竭疾病中最常見的併發症為次發性副甲狀腺機能亢進（secondary hyperparathyroidism）。目前臨床上，最常用於治療次發性副甲狀腺亢進的藥物為磷結合劑（phosphate binders）、維生素D（vitamin D）、擬鈣劑（calcimimetics），甚至到嚴重的副甲狀腺亢進且伴隨有藥物阻抗情形，則必須執行副甲狀腺切除術（parathyroidectomy）。本文將探討慢性腎臟病造成次發性副甲狀腺亢進的機轉和治療方法。
並列摘要
Chronic kidney disease leads to abnormalities of bone and mineral metabolism which is called renal bone disease generally. It is probably reported disorder of calcium (Ca), phosphorus (P), parathormone (PTH) and active vitamin D deficiency. However, the most common complication is secondary hyperparathyroidism. In clinical, current drug therapies included phosphate binders, active vitamin D compounds and calcimimetics. Patient should received parathyroidectomy, if patient with severe hyperparathyroidism accompanied by drug resistance. This review article will discuss the mechanism and management of secondary hyperparathyroidism result from chronic kidney disease.