This report was about a nursing care experience of a sigmoid colon cancer patient with postoperative wound infection. The period of nursing care was from 21st June to 12th July, 2010. The patient's data was collected and evaluated by means of direct caring, observation, medical reports and patient's interview in physical, psychological, social, and spiritual fields. The patient's health problems were pain, actual infection, anxiety, and lack of caring knowledge. During the nursing care process, empathy, company, listening, and supporting were the great methods to assist the patient to overcome his anxiety of post-operation; furthermore, help him learn what the self-care procedures were, and help him learn how to get along with pain so that the patient could avoid the wound infection and relieve the physical suffering. Thus, the patient gained the ability of self care and positive experience of hospitalization.