The Evaluation of Differences of 3D-CRT, IMRT and VMAT Radiotherapy Planning for Prostate Cancer

以3D-CRT, IMRT及VMAT治療計畫評估攝護腺癌治療劑量研究

Than Van Viet ； Jao-Perng Lin ； Tran Van Viet ； Yi-Chi Liu ； Nguyen Tuan Anh

《台灣應用輻射與同位素雜誌》 14卷4期 (2018/12) Pp. 1665-1672

摘要

Nowadays, radiation therapy comes to the standard treatment for prostate cancer. There are many critical Organ at Risks (OARs) can be affected during and after the treatment, which can negatively affect patients' later life. In our study, we made comparisons in terms of the optimal dose to target as well as sparing dose to OARs among three techniques 3D-CRT, IMRT and VMAT of prostate cancer. Ten of prostate cancer patients after being treated by IMRT were recruited. The dose influence in PTV was evaluated by Homogeneity index (HI) and Conformation index (CI). Monitor units (MUs) and treatment time (TT) were compared. Three treatment planning met the target coverage (over 95% prescription) and dose distribution. However, IMRT and VMAT showed the optimal dose in mean dose in the target, p＜0.05. Besides, distribution dose in OARs of IMRT and VMAT was significantly lower comparing with 3D-CRT planning, p＜0.05. MU of IMRT (793.4±37.2) planning illustrated higher than 3D-CRT (305.5±19.80) and VMAT (483.8±21.3). VMAT planning was successful in reducing MU and treatment time. Our study demonstrated that VMAT planning was significantly better in planning quality compared with 3D-CRT and IMRT in the optimal dose to target, OARs and treatment time.

關鍵字

PTV ； OARs ； Prostate Cancer ； Dosimetry ； 3D-CRT ； IMRT ； VMAT

參考文獻

Aoki, J,Kirtane, A,Leon, MB(2008).Coronary artery aneurysms after drug-eluting stent implantation.JACC Cardiovascular Intervention.1,14-21.

Schoenhagen, P,Ziada, KM,Vince, DG(2001).Arterial remodeling and coronary artery disease: the concept of “dilated” versus “obstructive” coronary atherosclerosis.Journal of the American College of Cardiology.38,297-306.

Ashman, JB,Zelefsky, MJ,Hunt, MS(2005).Whole pelvic radiotherapy for prostate cancer using 3D conformal and intensitymodulated radiotherapy.Int J Radiat Ooncol Biol Phys.63,765-771.

Cakir, Aydin,Akgun, Zuleyha,Fayda, Merdan,Agaoglu, Fulya(2004).Comparison of Three Dimensional Conformal Radiation Therapy, Intensity Modulated Radiation Therapy and Volumetric Modulated Arc Therapy for Low Radiation Exposure of Normal Tissue in Patients with Prostate Cancer.Asian Pac J Cancer Prev.16(8),3365-3370.

Boersma, LJ,van den Brink, M,Bruce, AM,Shouman, T,Gras, L,te Velde, A,Lebesque, JV(1998).Estimation of the incidence of late bladder and rectum complications after high-dose (70-78 GY) conformal radiotherapy for prostate cancer, using dose-volume histograms.Int J Radiat Oncol Biol Phys.41,83-92.