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Abstracts


微血管增生(angiogenesis)對於運動訓練提昇氧化能力扮演著舉足輕重的角色。肌肉組織發展出廣大的微血管網絡,肌細胞與微血管腔間的養份運送及廢物排除獲得改善,進而提昇氧化代謝能力。Prior, Yang, and Terjung(2004)指出分歧型微血管增生可能是運動訓練後微血管形成的主要方式。在分子生物的層級上,許多的生長因子與運動導致微血管增生具密切相關,包括血管內皮細胞生長因子(vascular endothelial growth factor, VEGF)、基礎纖維母細胞生長因子(basic fibroblast growth factor, bFGF)、血管生成素(angiopoietin)、轉型生長因子-β1(transforming growth factor, TGF-β1)及基質金屬蛋白酶(matrix metalloproteinases, MMPs),其中以VEGF不需其它因子的協助,可直接影響微血管增生最為重要。

Parallel abstracts


Angiogenesis plays a central role in the improvement of oxidative capacity following exercise training. Expansion of the capillary network, a process termed angiogenesis, is effective at improving exchange properties between the vascular space and the intracellular volume of the fiber. Recent research has suggested that sprouting angiogenesis may be the primary way of capillary formation after exercise training. A number of important angiogenic factors were closely associated with exercise-induced angiogenesis, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiopoietin, transforming growth factor-β1 (TGF-β1), and matrix metalloproteinases (MMPs). Furthermore, VEGF appears to be a very important element in angiogenesis because VEGF has been shown to act without the other angiogenic factors.

Parallel keywords

Exercise Angiogenesis VEGF

References


李元民、徐菡怡(2002)。新生血管生成素Angiogenesis。中華民國醫檢會報。17(2),31-35。
林正常(2002)。運動生理學。台北市:藝軒。
潘震澤(1999)。人體生理學。台北市:合記。
Adolfsson, J.,Ljungqvist, A.,Tornling, G.,Unge, G.(1981).Capillary increase in the skeletal muscle of trained young and adult rats.Journal of Physiology.310,529-532.
Bernatchez, P. N.,Soker, S.,Sirois, M. G.(1999).Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent.Journal of Biological Chemistry.274(43),31047-31054.

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