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間歇性低氧對葡萄糖耐受度與胰島素敏感度的影響

The Effect of Intermittent Hypoxia on Glucose Tolerance and Insulin Sensitivity

Abstracts


運動訓練有效提昇葡萄糖耐受度與胰島素敏感度已獲得研究證實。目的:觀察不同的間歇性低氧對於葡萄糖耐受度與胰島素敏感度的影響。方法:實驗設計將39隻SD雄性鼠以體重配對方式進行分組:每日低氧剌激一小時(n=13)、每日低氧剌激八小時(n=13)與常氧對照組(n=13)。在各組中一半動物進行一週的實驗介入,剩餘的一半將持續實驗介入八週。低氧介入時,使受試動物呼吸於14%氧氣濃度的常壓低氧環境,實驗介入結束後十三小時立即實施口服葡萄糖耐受性測驗。結果:發現一週間歇性低氧結束後,八小時組顯著提昇葡萄糖耐受度,但未能改變胰島素的反應。八週間歇性低氧結束後,一小時組與八小時組皆能顯著提昇胰島素敏感度。結論:間歇性低氧可提昇葡萄糖耐受度與胰島素敏感度,其程度受實施時間的影響。

Parallel abstracts


The benefit of exercise training on glucose tolerance and insulin sensitivity has previously been demonstrated. The current study was undertaken to investigate the effect of the different intermittent hypoxia on the glucose tolerance and insulin sensitivity. Thirty-nine Sprague-Dawley rats were matched for weight and assigned into following 3 treatments: control (n=13), 1-hr hypoxia/day (n=13), and 8-hr hypoxia/day (n=13). Half of the animals in each group were exposed to hypoxia for one week, and the rest of animals were continuously exposed to hypoxia until 8th weeks. Hypoxic treatment consisted of breathing 14% O2 under normobaric condition. An oral glucose tolerance test (OGTT) was performed 13h after treatments. At the end of the one week, 8-hr hypoxia/day significantly improved glucose tolerance, but did not alter insulin response. At the end of the 8th weeks, both 1 and 8-hr hypoxia/day significantly improved insulin sensitivity. This result indicated that intermittent hypoxia improved glucose tolerance and insulin sensitivity. The level of the improvement could were associated with the effect of hypoxia duration and period.

References


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