Aging induced loss of muscle power, which affects physical fitness and function. Exercise with oral DHEA-S had been demonstrated to improve muscle power of the elderly, while the effect of exercise training on endogenous DHEA-S and the association between DHEA-S and the exercise effect was unknown. Hence, this study was to investigate the changes in endogenous DHEA-S after exercise training and the association of the improvement in physical fitness after training and DHEA-S of the elderly. Twenty-four community-dwelling sedentary elderly (age=71.50±0.90 years, BMI=25.50±0.70 kg/m^2) were involved in 16-week multiple exercise training. DHEA-S and physical fitness including body composition (muscle mass, muscle percent, fat mass and fat percent), functional strength (grip and functional low extremity muscular power), cardiopulmonary fitness and balance ability were measured pre- and post-training. The results showed that DHEA-S level after training significantly increased (3.98±1.27 to 9.14±1.86 ng/ml, p=.027). Significant increase was noted in muscle percent and decrease in fat mass as well as fat percent (p<.0001). Left-hand grip increased from 21.30±1.30 to 23.20±1.50 kg (p=.032) and the time of 8-foot up-and-go test decreased from 8.20±0.30 to 5.50±0.10 sec (p<.0001). The time of both stand with eye-open and eye-close significantly increased (p<.05), while the reactive time to sound and light also increased (p<.05). The 6-min walk test significantly increased from 448.40±12.00 to 482.30±11.70 m (p=.001). No significant correlation was noted between the changes in DHEA-S and most measurements of physical fitness. These results showed that multiple exercise training in this study could enhance DHEA-S level, reduce fat content and improve functional strength, cardiopulmonary fitness and balance of the elderly. However, the change in DHEA-S level was unable to totally reflect the changes in physical fitness. Further investigation of the association of DHEA-S and the exercise effect was required.
Aging induced loss of muscle power, which affects physical fitness and function. Exercise with oral DHEA-S had been demonstrated to improve muscle power of the elderly, while the effect of exercise training on endogenous DHEA-S and the association between DHEA-S and the exercise effect was unknown. Hence, this study was to investigate the changes in endogenous DHEA-S after exercise training and the association of the improvement in physical fitness after training and DHEA-S of the elderly. Twenty-four community-dwelling sedentary elderly (age=71.50±0.90 years, BMI=25.50±0.70 kg/m^2) were involved in 16-week multiple exercise training. DHEA-S and physical fitness including body composition (muscle mass, muscle percent, fat mass and fat percent), functional strength (grip and functional low extremity muscular power), cardiopulmonary fitness and balance ability were measured pre- and post-training. The results showed that DHEA-S level after training significantly increased (3.98±1.27 to 9.14±1.86 ng/ml, p=.027). Significant increase was noted in muscle percent and decrease in fat mass as well as fat percent (p<.0001). Left-hand grip increased from 21.30±1.30 to 23.20±1.50 kg (p=.032) and the time of 8-foot up-and-go test decreased from 8.20±0.30 to 5.50±0.10 sec (p<.0001). The time of both stand with eye-open and eye-close significantly increased (p<.05), while the reactive time to sound and light also increased (p<.05). The 6-min walk test significantly increased from 448.40±12.00 to 482.30±11.70 m (p=.001). No significant correlation was noted between the changes in DHEA-S and most measurements of physical fitness. These results showed that multiple exercise training in this study could enhance DHEA-S level, reduce fat content and improve functional strength, cardiopulmonary fitness and balance of the elderly. However, the change in DHEA-S level was unable to totally reflect the changes in physical fitness. Further investigation of the association of DHEA-S and the exercise effect was required.