- 期刊
GMTA和20%DFC應用於乳牙冠髓切除術：追蹤12個月臨床試驗之配對樣本分析
Comparison of Mineral Trioxide Aggregate and Diluted Formocresol in Pulpotomized Human Primary Molars: A 12-month Follow-Up Study
摘要
本研究為前瞻性隨機分派的配對樣本臨床試驗，目的為比較灰色三氧礦化聚合物（Gray Mineral Trioxide Aggregate，GMTA）與20% Formocresol（20% Diluted formocresal, DFC）在臨床應用與放射線學檢查的療效。本研究招募自2011年7月至2013年1月31日止，於台灣大學附設醫院牙科部兒童牙科招募同時有兩顆以上的乳臼齒必須進行乳牙冠髓切除術的受試者。一共有32位的健康正常孩童，共76顆乳臼齒（DFC組有38顆，GMTA組有38顆）參與本試驗，追蹤的時間為12個月。在術後12個月臨床治療成功率，GMTA組為100%，DFC組為97.4%，兩個組別在臨床成功率並未有統計上的顯著差異。在放射線學成功率方面，GMTA組在12個月的成功率為100%，DFC組的成功率為89.5%，兩個組別在放射線學成功率尚未達到統計上的顯著差異（p＞0.05）。在12個月的追蹤期間，GMTA組比DFC組有較高的比例出現牙本質屏障生成，而DFC治療後的乳牙有較高比例出現根管鈣化的情形，這兩項發現都有統計上的顯著差異（P＜0.05）。
並列摘要
The purpose of this study is to establish a prospective clinical randomized controlled trial (CRT) for assessing the clinical and radiographic outcomes between gray mineral trioxide aggregate (GMTA) and dilute 20% formocresol (DFC) in pulpotomized human primary molars. To assess this goal, 76 primary molars from 32 patients of Department of Pediatric Dentistry of National Taiwan University Hospital were randomly assigned to GMTA group or DFC group. Clinical success was 100% in GMTA group and 97.4% in DFC group within 12-month follow-up period. There was no significant difference in the clinical success rate between GMTA and DFC groups. Radiographic success was 100% in GMTA group and 89.5 in DFC group within 12-month follow-up period. There was also no significant difference in the radiographic success rate between GMTA and DFC groups. More teeth with dentinal bridge were found in the GMTA group than in the DFC group at all follow-up periods. More teeth with pulp canal obliteration were observed in the DFC group than in the GMTA group within 12-month follow-up. Teeth with internal root resoprtion were only found in DFC. Based on the results of this study, GMTA appears to be a replacement pulpotomy agent for DFC in primary dentition.