- 期刊
某醫學中心第三期結直腸癌病患化學治療副作用變化之前瞻世代研究
A Prospective Cohort Study on Perceptions of the Side Effects of Chemotherapy for Patients with Stage III Colorectal Cancer
摘要
目的：了解第三期結直腸癌病人化療副作用嚴重程度並追蹤一年內每三個月發生率與嚴重度之變化情形。方法：收案時間為2020年11月12日至2022年12月9日間在某醫學中心大腸直腸外科病房接受FOLFOX治療方案之手術後第三期結直腸癌病人，共收案118人，每位樣本均完成4次訪問；分別於第一次化療（約於住院期間第二天）、化療後3個月（約第6個療程）、最後一次化療結束（5～6個月；約第9～12個療程）以及化療結束後3個月再以電訪追蹤副作用（第4次）；每次訪問約需5～10分鐘。研究工具採用「歐洲癌症治療與研究組織發展之化學治療周邊神經病變」量表，該量表經逆向翻譯（back translation），以確認其信效度。每三個月之化療副作用變化情形以McNemar test進行分析。結果：研究樣本屬性以男生居多（61%），平均年齡為60.5±11.1歲，主要診斷為大腸癌（66.1%），期別以IIIB比率最高（60.2%）。副作用嚴重程度及其變化依照維持好、維持不好、改善與變嚴重的比率可分為三種類別；20個副作用中，4項（手腳「針刺感」與「麻木」）屬低發生率高嚴重度，10項屬低發生率中嚴重度，6項屬低發生率低嚴重度。結論：大部份第三期結直腸癌病人化療副作用屬低發生率中嚴重度。
並列摘要
Purpose. To understand the severity of chemotherapy side effects of every three months in one year for colorectal cancer patients. Methods. A prospective cohort study, we recruit 118 stage III colorectal rstcancer patients after surgery who were accepted with chemotherapy. All participants were completed 4 interviews: the first time of chemotherapy (on the second day of hospitalization), 3 months after chemotherapy (approximately the 6th course of treatment), and the last chemotherapy (5 to 6 months; approximately the 9th to 12th course of treatment) After the end of chemotherapy and 3 months after the end of chemotherapy, follow-up side effects were followed by telephone interviews (the 4th time). The interview tool of EORTC QLQ-CIPN20 scale was back translated to confirm its reliability and validity. The changes in chemotherapy side effects of every three months were analyzed using McNemar test. Results. The study sample were mostly male (61%), the average age was 60.5±11.1 years old, main diagnosis was colorectal cancer (66.1%), and the stage IIIB rate was the highest (60.2%). The severity of side effects and their changes can be divided into three categories according to the distribution of good maintenance, poor maintenance, improvement and seriousness: divided into "high incidence and high severity", "low incidence and high severity" and "low incidence". Among the 20 side effects, 4 ("pins and needles" and "numbness" in hands and feet) are of low incidence and high severity, 10 are of low incidence and medium severity, and 6 are of low incidence and low severity. Conclusion. Chemotherapy side effects for most stage III colorectal cancer patients are low in incidence and medium in severity.