A 84-year-old male patient received radiotherapy because of prostate cancer, and results in radioactive colonitis which further develops into complications such as colon-bladder fistula. TCM diagnosis is deficiency of normal qi with ligering of evil qi and dual qi and blood deficiency. A satisfying result is reached by prescribing TuoLiXiaoDuYin to supplement qi and blood, to eliminate toxin and sweling. It is clear that TCM has its advantages in treating sequla of radiotherapy, and it will provide a precious direction for future relevant clinical trials.