Nowadays the conference diagnosis on Traditional Chinese Medicine (TCM) treatment puts emphases on the thoughts of holistic care, the differentiation of syndromes and the differentiation of diseases that are combined with medication, surgery, radiotherapy and chemotherapy to treat patients. In this report we present a conference case of lung adenocarcinoma (pT4N3MI, stage Ⅳ) with superior vena cava syndrome (SVCS) in a 67-year-old female who had undergone palliative radiotherapy and chemotherapy but tumor still expanded and compressed SVC which led to SVCS. Due to her suffering from short of breath, incapability of lying down, severe cough, and generalized edema, Traditional Chinese Medicine was consulted. After differentiating syndromes of the patient, we prescribed a remedy to supplement qi, promote blood circulation to remove blood stasis, purge the lung and resolve phlegm, regulate the flow of qi and relieve depression in the chest, nourish kidney and absorb qi, and activate Yang and induce diuresis. All the above-mentioned ways were used to help the patient improve the symptoms and elevate the quality of life. In the progress of prescribing, we found it is the mechanism of the disease and the anatomy relative to diverse symptoms to approach a better curative effect.