A 76-year old female patient was suspected suffering malignant hepatocellular carcinoma from other personal clinic. The liver tumors were found to locate at S4/5 11.4 cm and S3 2.6 cm cm by abdominal ultra- sona and computed tomography, It was diagnosed T3bN0M0 as hepatocellular carcinoma. The arterial embolization (TAE) treatment was perfomed at 7th day after hospitalized. However; the persist tide fever cold-like malaria was continued despite the antibacterial drugs usage began the 2nd day after hospitalized . The Traditional Chinese Medicine (TCM) Doctor was consulted to solve the tide fever at 8th day (the 2nd day of TAE) after hospitalized. TCM treatment combined with TACE was prescribed according to syndrome differentiation to overcome tide fever. The Sho-Saiko-To of TCM treatment was prescripted and combined with Modem Western Medicine. It has also been shown to improve immune system functions and inhibit hepatocellular carcinoma TAE tide fever. The temperature was normal and fever was non refundable, on the second day of consultations of TCM treatment (the eighth day in hospital). The patient was dicharged from hospital on the 14th day. A detailed mechanism combination of TCM and MWM was discussed in this article.