Edema is due to the imbalance of liquid between vessels, lymph system and tissues, causing the accumulation of liquid within body, mostly exhibited as lower limb edema. Edema might be one clinical performance in the development of many diseases; therefore, it is essential for the efficacy of treatment to analyze the real causes of the edema, especially the inquiry of past medical and medicine history to collecting useful data carefully. This case report presented a 22-year-old female with swelling and pain in lower limb regarding the process of receiving Traditional Chinese Medicine, the possible causes and mechanism of her edema and the efficacy of the combined herbs used.