細菌纖維素於生醫材料之應用

Application of Bacterial Cellulose in Biomedical Materials

陳頤之(Yi-Jr Chen) ； 陳思萍(Sy-Ping Chen)

《長庚科技學刊》 27期 (2017/12) Pp. 77-86

https://doi.org/10.6192/CGUST.201712_(27).9

摘要

細菌纖維素是高純度、耐高溫、耐強鹼之微細纖維網狀聚合物，其具備高通透性、高保水性、高結晶度、高機械強度及良好生物相容性等獨特性質。因此，研究人員致力於利用細菌纖維素製成各類新型生醫材料，包括創傷敷料、人工血管、藥物傳輸系統等。本文回顧新近文獻，探討細菌纖維素的特性及生醫材料之應用。

關鍵字

細菌纖維素 ； 生醫材料 ； 創傷敷料 ； 人工血管 ； 藥物輸送系統

並列摘要

Bacterial cellulose is heat and alkali resistant ultra-fine and highly pure polymer fibrous network. It displays several unique properties, including high permeability, high water absorption capacity, high crystallinity, high mechanical strength, good biocompatibility, etc. Therefore, researchers endeavor to use bacterial cellulose to develop novel biomedical materials in the biotechnology industry, e.g., wound dressing, artificial blood-vessels, and drug delivery systems. The purpose of this article is to review current literature of the characteristics and the applications of bacterial cellulose as biomedical materials.

並列關鍵字

bacterial cellulose ； biomedical materials ； wound dressing ； artificial blood-vessel ； drug delivery system

參考文獻

Abeer, M. M., Amin, M., Iqbal, M. C., & Martin, C. (2014). A review of bacterial cellulose-based drug delivery systems: their biochemistry, current approaches and future prospects. Journal of Pharmacy and Pharmacology, 66 (8), 1047-1061.

Amin, M. C. I. M., Ahmad, N., Halib, N., & Ahmad, I. (2012b). Synthesis and characterization of thermo-and pH-responsive bacterial cellulose/ acrylic acid hydrogels for drug delivery. Carbohydrate Polymers, 88 (2), 465-473.

Bodin, A., Backdahl, H., Fink, H., Gustafsson, L., Risberg, B., & Gatenholm, P. (2007). Influence of cultivation conditions on mechanical and morphological properties of bacterial cellulose tubes. Biotechnology and Bioengineering, 97 ,425-434.

Czaja, W., Krystynowicz, A., Bielecki, S., & Brown, R. M. (2006). Microbial cellulose–the natural power to heal wounds. Biomaterials, 27 (2), 145-151.

Fink, H., Hong, J., Drotz, K., Risberg, B., Sanchez, J., & Sellborn, A. (2011). An in vitro study of blood compatibility of vascular grafts made of bacterial cellulose in comparison with conventionally-used graft materials. Journal of Biomedical Materials Research, Part A, 97 (1), 52-58.