摘要
孕婦膽汁鬱滯的主要表現為有皮膚癢和血清中膽酸增加，多發生在第三孕期。對胎兒之嚴重影響包括羊水呈胎便色、早產、胎兒窘逼、和死產。其產生原因不明，可能因控制肝細胞運輸系統的基因異常，使肝臟至膽道之分泌受阻。現階段認為使用ursodeoxycholic acid對改善母體症狀和肝功能之效果最佳。孕婦一旦被診斷出在懷孕中有膽汁鬱滯，除口服ursodeoxycholic acid外，並需嚴密監視胎兒，一旦胎兒肺臟已成熟，便需立即生產，以避免胎兒發生不幸。
並列摘要
Intrahepatic cholestasis of pregnancy occurs mainly in the third trimester and is characterized by puritus and elevated serum bile acid levels. It has been associated with poor perinatal outcomes including higher rates of meconium-stained amniotic fluid, preterm birth, fetal distress and intrauterine stillbirth. Although the pathogenesis of this disease is unknown, a genetic hypersensitivity to female hormones or their metabolites is though to impair bile secretory function. The most efficacipus current medical treatment that improves both maternal symptoms and liver function is ursodeoxycholic acid. When intrahepatic cholestasis of pregnancy is diagnosis, ursodeoxycholic acid coupled with frequent maternal-fetal surveillance is indicated. Delivery should be effected near term, with confirmation of fetal lung maturity or earlier if fetal compromise is identified.