- 期刊
Reverse Iontophoresis: A New Approach to Measure Blood Glucose Level
並列摘要
This study focused on the investigation of the possibility of monitoring blood glucose levels in humans by non-invasively extracting glucose and lactate from blood through the skin using reverse iontophoresis. In vitro reverse iontophoresis studies have indicated that the optimum switching mode for reverse iontophoresis of lactate and glucose are continuous direct current and direct current with electrode polarity reversal every 15 minutes, respectively. The application of a current combined with electrode polarity reversal every 15 minutes has been suggested for use in humans. The reverse iontophoresis technique was applied to 10 healthy volunteers. Glucose and lactate were successfully extracted through the subjects' skin into the methylcellulose gel of the electrodes. A fair-good correlation (r^2=0.62) between the subject‘s blood glucose level and the ratio of glucose to lactate levels in the collection gels was observed after two outliers were removed from the regression equation. The result suggests that it may be possible to non-invasively monitor the blood glucose levels using this new approach free of the need for calibration with a blood sample.