The differential diagnosis of LUTS/BPH is an important issue need to be addressed since the accurate diagnosis and appropriate prescription is only around 10% for both BPH and OAB diseases. The more different specialists involved in this field, the more inadequate treatment will be. This is because that we usually treat LUTS as a very simple situation suggestive of BPH. This is not true. The same clinical presentations may have totally different anatomic or functional problems. A large proportion of overlap in the diagnosis of BPH and OAB is almost over than 60%. In addition, the bladder outlet obstruction such as BPH may induce secondary bladder detrusor muscle changes. This will cause a more complicate clinical presentation. As a result, a special training including how to make a differential diagnosis and sometimes the urodynamic based diagnosis is beneficial and unavoidable. By introducing a 2 × 2 diagnostic grid, we can therefore familiar with more than one single diagnosis. In actuality, combined diagnosis is not uncommon in our daily practice. To approach a patient with BPH is just like to peeling off an onion; finally, we will find something new and something different which is out of our expectation. Based on a 2 × 2 diagnostic grid, one can be easier to analyze the voiding problem. This is not a simple problem of α-blocker or 5-α reducatase inhibitor.