The cylinder flows structure is important part in the transverse-flow CO_2 laser, which affects the internal gas flow, and influences the flow kinetic energy loss. To study structural optimization to reduce the flow kinetic energy loss is a key concern of designers. In this study, the dynamic mesh model is used to simulate the rotation of cross-flow fan, the calculation process shows that it is easy to understand how to set parameter and treat mesh. Through optimization analysis on six structure parameters of the cylinder flow, we obtain the results that some of the parameters significantly influence the mixture gas velocity distribution in the discharge domain, but some other parameters of the flow field less affected velocity distribution of the discharge domain. The variation trends of the velocity distribution is also inconsistent which impacted by variation of each parameter. Through comprehensive analysis, the results of the optimization are: 1=14; 2=67.9; 3=73.1; 4=9.5; 5=65.6; 6=41.7. By validation calculations for the optimized structure of cylinder flow, we obtain the results that the flow state of discharge domain in the optimized structure is better than that of the previous structure.