In order to investigate the complex natures of non-Newtonian fluid flow in the horizontal wells during ASP (Alkaline/Surfactant/Polymer) flooding, a full-scale experimental facility has been designed and constructed, based on which a series of studies upon oil and ASP solution two-phase flow in a horizontal concentric annulus are conducted. The working fluids are self-made ASP solution and the mineral white oil. Results show that under the experimental conditions, the flow pattern is dominated by the dispersed flow while the alternative stratified flow is rarely seen. Similar to the single-phase flow, the pressure drop of oil and ASP two-phase flow has also an approximate exponential relationship with the mixture flow rate and first increases and then decreases with increasing the input oil volumetric fractions. The critical oil cut at which the phase inversion occurs is between approximately 30 and 40%. The achievements obtained in this study is a foundation for developing and validating the corresponding model with respect to the pressure drop of oil and ASP two-phase flow in an annuli.