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Evaluation Analgesic, Anti-Inflammatory and Antiepileptic Effect of Hydro Alcoholic Peel Extract of "Punica granatum (pomegranate)"

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Punica granatum L. is a w idely used plant that has high nutritional value. The aim of present study was evaluation analgesic, anti-inflammatory and antiepileptic effect of Pomegranate Peel Extract (PPE) in mice. Hydro alcoholic peel extract of pomegranate was prepared by maceration method. In the first study the number of writhing was counted within 10 min in one group of mice after 10min later to acetic acid injection intraperitoneally. In other group, the extract was intraperitoneally administrated at dose 400mg/kg by 20min before acetic acid injection and the number of writhing was counted as later group. In formalin test; the formalin was subcutaneously injected in foot of mice. The licking time of foot was calculated 5 and 15-25min after formalin injection. In other group, test was done as previous but the extract was intraperitoneally administrated 400mg/kg by 20min before formalin injection. In the second study; the mice were divided in to 6 groups. One group of mice received strychnine at dose 3mg/kg as negative control. Other group received Phenobarbital before strychnine administration as a positive control. In 4 groups of mice, the PPE was administrated at 100, 200, 400 and 600mg/kg before strychnine administration. The onset, duration and number of convulsion were measured and time of death was determined in 30min after strychnine administration. The results of first study showed that pomegranate peel extract was considerably decreased licking and writhing. The results of second study showed the PPE had significantly anticonvulsive effect. Thus, PPE has analgesic, anti-inflammatory and antiepileptic effect.

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